Cisplatin gsh

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August undefined, 2024

WebEbselen is a seleno-organic compound with documented cytoprotective properties. Little work has been done, however, demonstrating ebselen's cytoprotective prop WebAug 8, 2010 · Cisplatin can bind to the thiol group of intracellular glutathione (GSH) and this reaction is considered important for the inactivation of cisplatin . However, Gibson and coworkers recently suggested that binding of cisplatin to GSH is not the most important cellular interaction for inactivation ( 17 ).

Intracellular glutathione-depleting polymeric micelles for cisplatin …

WebThree mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may … WebNeurotoxicity is an obvious adverse effect in Patients encountering a complete course of chemotherapy. The present work is conducted to evaluate the neuroprotective effect of Ginkgo biloba (Ginkgo) against the neurotoxicity induced by Cisplatin (Cis) in rats. Forty male Wistar albino rats were arranged into four groups: (1) Control group, rats were … five9/wfm servicenow request form

Nitric oxide and cisplatin resistance: NO easy answers

WebJul 1, 2013 · GSH concentration was measured with UV-Visible double beam spectrophotometer, using the Ellman’s method. The level of GSH was lowered upon addition of cisplatin to plasma and cytosolic... WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose … WebSep 18, 2024 · NCBI Bookshelf canine agility of central minnesota

“Pincer movement”: Reversing cisplatin resistance based …

A GSH-depleted platinum(IV) prodrug triggers ... - ScienceDirect

WebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. WebResults: Serum GSH content depleted significantly after a total dose of 4 Gy and 10 Gy of radiotherapy with a single dose of cisplatin, which was significantly lesser in NR than of CR patients. Similarly, Olive Tail Moment, the index of DNA damage, indicated significantly higher values in the fifth fraction of radiotherapy (5-RT) than in ... five9 windows firewallWeb(GSH) transferase activity of GST P1-1. Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity. Furthermore, it is well known that GST P1-1 binding to the c-Jun N-terminal kinase (JNK) inhibits JNK phosphory- canine age chart

"WebNov 1, 2015 · Increased GSH level has been associated with cisplatin resistance [11], [12], [13]. Cystine, the rate-limiting amino acid for GSH synthesis, is transported by the xc − system composed of heavy subunit F42hc, a common component for amino acid transport and the active subunit xCT [21]. " - Cisplatin gsh

Cisplatin gsh

Sensitization of non-small cell lung cancer cells to cisplatin by ...

WebFeb 1, 2012 · Recently, Volckova, et al. [17] used a variety of physical techniques to show that GSH rapidly reduces iproplatin, 2, to produce cis -di (isopropylamine)chloro-glutathionatoplatinum (II) which has the thiolate of a GSH molecule bound to Pt (II). WebFeb 12, 2024 · Cisplatin, [Pt (NH 3) 2 Cl 2] (CDDP), is a potent chemotherapeutic agent used for several types of cancer, e.g. carcinoma of the ovary, testicle, head and neck, bones, brain, lymph node, and skin. 1,2 CDDP still represents the elective cytotoxic agent for the treatment of the carcinoma of the ovary, which is the leading cause of death …

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WebPubMed Central (PMC) WebJul 29, 2024 · Glutathione (GSH) is the most abundant non-protein thiol in cells and plays a critical role in maintaining intracellular redox homeostasis. 1 Alterations in glutathione levels are associated with several cellular …

WebIndeed, GSH can bind cisplatin forming cisplatin-GSH adducts which are exported from the cells through the multidrug resistance protein-2 (MRP-2) efflux pump, thus reducing the intracellular ... WebOxidative stress caused by cisplatin, evidenced by increases in kidney tissues malondialdehyde (MDA) content, cytochrome P450 E1 (CYP2E1), renal 4-hydroxynonenal (4-HNE) levels and decreases of glutathione (GSH) and superoxide dismutase (SOD) contents, was significantly ameliorated by AGBE pretreatment.

WebMar 10, 2024 · Considering glutathione (GSH) is the most abundant source of thiols in tumor cells and the concentration of GSH in cisplatin-resistant cells is frequently higher than that in cisplatin-sensitive cells, it is of great significance to control the GSH level in cancer cells for cisplatin-based treatment toward cisplatin-resistant cancers [7], [30], … Webized GSH concentration as compared to cisplatin alone (table 2). The renal GSH and oxidized GSH concentrations in lipoic acid alone treated group were 19.93”2.39 and 1.14”0.12 nmoles/mg protein which were close to control values. Superoxide dismutase activity in the kidney signiﬁcantly decreased (62% of control) in cisplatin-treated rats ...

WebNov 27, 2024 · It is well established that one of the main factors that promote intracellular cisplatin detoxification is GSH, since it can bind covalently to the drug and prevent it to …

WebMar 20, 2024 · GSH-depleting agents buthionine sulfoximine is a useful agent for inhibition of γ-glutamylcysteine ligase, and it reduced the resistance to cisplatin in malignant glioma (Rocha et al., 2015). However, non-specific GSH depletion can cause irreversible damage in most normal tissues. canine age by teethWebThe widespread damage to the seminiferous epithelium induced by cisplatin administration was less severe in mice simultaneously treated with ghrelin. Furthermore, ghrelin … five9 whatsappWebApr 1, 2016 · Cisplatin is also inactivated by glutathione-s-transferase, which add a glutathione (GSH) to cisplatin. The conjugated cisplatin-GSH is then exported via the MRP2 transporters. Cisplatin is also exported by ATP7A and ATP7B. Inactivation of cisplatin can also result from binding metallothionein proteins (MT). five9 workstation sofphoneWebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … five 9 wfo communityWebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台 canine age spotsWebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … five9 x3000WebFeb 17, 2024 · The results showed that levels of glutamine, glutamate, and glutathione (GSH), a key drug resistance mediator synthesized from glutamate, were significantly elevated in A2780cis cells than those in A2780 cells. Furthermore, glutamine starvation decreased the GSH levels and CDDP resistance in A2780cis cells. five9 youtube