Cisplatin mouse

Author: apgy

August undefined, 2024

WebMay 26, 1998 · Cisplatin is used to treat a wide variety of cancers in addition to testicular tumors (3, 4), although its effectiveness is often limited by its inherently poor activity against many tumor types and by the development of resistance . WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

Granulocyte-colony stimulating factor does not prevent in vitro ...

WebJan 18, 2024 · Cisplatin-induced DNA damage maps across mouse organs. Here, we adopted a previously developed high-throughput sequencing protocol, Damage-seq 15, for assaying genome-wide DNA damage with single ... WebOct 7, 2024 · Abstract 1. Introduction In 2024, 18.1 million new cases and 9.5 million cancer-related deaths were diagnosed worldwide. It is... 2. Cisplatin Mouse Models Cisplatin … east mckeesport police department

Chronic effects of repeated low-dose cisplatin treatment in mouse

WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, mice bearing A549/DDP cells were sacrificed and the organs were excised for ex vivo imaging. Ex vivo fluorescent imaging showed a strong signal in tumors, heart, liver, ... WebJul 4, 2024 · Cisplatin administered on the day of wounding decreased tumor burden by 50%, as compared to 90% in unwounded animals. Cisplatin on day 7 or day 28 decreased tumor burden by 80 and 37% respectively. Conclusions Surgical wounding increases ovarian tumor mass and decreases perioperative cisplatin efficacy in this animal model. WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … culture is stable and yet it changes

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

Cisplatin nephrotoxicity as a model of chronic kidney disease

WebCisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive surgical debulking. WebMay 11, 2012 · Mice were given LPs-pVAX or LPs-pVAX-LKB1 complexes by intratumoral injection at a dose of 20 μg per mice and/or low-dose cisplatin (2 mg kg −1 per mice) by i.p injection. After 24 h of the ... east mckinney redevelopmentWebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by … east mckeesport zip code

"WebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, … " - Cisplatin mouse

Cisplatin mouse

Differential damage and repair of DNA-adducts induced by

WebFeb 18, 2024 · C57BL/6 mice were intraperitoneally injected with cisplatin (15 mg/kg) and then sacrificed at 8, 12, 24, and 72 h. A The body weight decreased 8–72 h after cisplatin treatment ( n = 4). B... WebCisplatin can cause fetal harm when administered to a pregnant woman. Cisplatin is mutagenic in bacteria and produces chromosome aberrations in animal cells in tissue culture. In mice cisplatin is teratogenic and embryotoxic. If this drug is used during pregnancy or if the patient becomes

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WebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar … WebAntitumor efficacy of aptamer‐siRNA nano‐zinc carriers in a mouse lung cancer model bearing A549/DDP cells. A549/DDP or A549 cells were implanted subcutaneously in nude mice. After 10 days, mice received a single intravenous injection of 5 mg/kg/d A10/NaZ/siUSP14#1 followed by serial fluorescence imaging at the indicated time points.

WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction ( Fig. 1 A–C). WebWe recently reported that human and mouse cells containing an African-specific coding region variant of p53, Pro47Ser (hereafter S47), are impaired in the transactivation of a small subset of p53 ...

WebCisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use.... WebDec 5, 2024 · Cisplatin also induces PD-L1 in tumor cells, suggesting dichotomous roles and supporting the need for combination with PD …

WebJun 1, 2024 · Cisplatin (CP) nephrotoxicity is a severe renal complication in patients receiving CP-based chemotherapy, but the incidence of AKI following CP chemotherapy is not well defined in humans. Recent...

WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute … culture is the body tadashi suzukiWebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... culture is the new currencyWebOur previous studies indicated that cisplatin administration to mice caused muscle atrophy. This is a concern for human patients receiving cisplatin. The insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt pathway stimulates the rate of protein synthesis in skeletal muscle. culture is the totality of learnedWebAug 28, 2024 · Three specific models using paclitaxel or cisplatin that stand out are 1) C57BL/6 female mice receiving paclitaxel and 2) CD1 male mice receiving paclitaxel and 3) C57BL/6 male mice receiving cisplatin. This overview may help scientists selecting suitable CIPN models for their research. culture is transmitted geneticallyWebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … culture is the soul of a country and a nationWebOct 29, 2024 · The aim of this study was to investigate the underlying protective mechanisms of maltol on nephrotoxicity by cisplatin using a cisplatin-treated mouse model and a cellular toxicity model of HEK293 ... culture is viewed as a macrosystemWebDec 24, 2024 · In this approach, cisplatin treatment was started when primary tumors were palpable (200–300 mm 3 ). When primary tumors bearing legs reached 15–17 mm (Day 35), three mice from control and... culture is the grammar of our behavior