Crm1 and p53
WebJul 3, 2013 · The CRM1 C-terminal domain lacking the NES-binding groove interacts with tetrameric p53, and the proper folding of the p53 core domain, rather than the presence of the N or C-terminal tails,... WebSep 23, 2007 · To test this, we co-transfected GFP–Crm1 with Flag–WT p53 or Flag–p53EDE/A into p53 −/− MEFs. Similar levels of GFP–Crm1 and Flag–p53 were …
Crm1 and p53
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WebJun 28, 2024 · Overexpression of CRM1 in cervical cancer cell lines reduced the nuclear retention of several tumor suppressors including p53, p27, p21, and p18. siRNA-induced inhibition of CRM1 in cervical cancer … WebOct 15, 2014 · High CRM1 expression was found to be associated with lytic bone disease (P = 0.008) and shorter survival (P = 0.024). CRM1 levels are higher in bortezomib resistant MM cells. SINEs caused nuclear accumulation of multiple TSPs including p53, FOXO3a, IκB, p21 and PP2A.
WebMay 1, 2015 · p53 Phosphorylation in Lung Tumors from NNK-Treated Mice and in NNK-Transformed Lung Epithelial Cells. CRM1 plays an important role in the transport of tumor suppressor and oncogene proteins, including p53, from the cell nucleus into the cytoplasm. 35, 36 Our previous study found p53 phosphorylation at Thr55 involved in CRM1 … WebCRM1 and Ran-GDP then diffuse back to the nucleus where GEFs exchange GDP to GTP . Because nuclear localization of proteins such as transcription factors is key to their function, and an adequate localization of signaling proteins close to their downstream targets can be imperative for many signal transduction pathways, unbalanced ...
WebIn the lesions, CRM1 expression was inhibited, and nuclear p53 levels were increased. Thus, CRM1-regulated p53 subcellular localization possibly affects lung cancer tumorigenesis (189).... WebDec 26, 2007 · This, in turn, exposes a nuclear export signal in p53 that stimulates Crm1-dependent exclusion of p53 from the nucleus. The physiological significance of this …
WebCRM1 inhibition rescued p53-dependent nuclear functions and sensitized NBAT1-depleted cells to genotoxic drugs. Combined inhibition of CRM1 and MDM2 was even more …
WebApr 4, 2009 · Crm1 is known to export p53 from the nucleus into the cytoplasm of cervical cancer cells via the C-terminal NES of p53, 28 a function that is promoted by HPV E6. 21 Additionally, nuclear export is required for the efficient degradation of p53 in high-risk HPV-infected cells, 28 although nuclear degradation of p53 does occur at low levels. 21 ... bambu argentina s.aWebSep 14, 2009 · In this study we show that p53 is required for the downregulation of FoxM1, an essential transcription factor that regulates many G2/M-specific genes and is … bambu artesanato em santa catarinaWebHere, we identify the major poly (ADP-ribosyl)ated sites of p53 by PARP-1 and find that PARP-1-mediated poly (ADP-ribosyl)ation blocks the interaction between p53 and the … arpadis ibericaWebJul 2, 2004 · This DNA damage-induced BRCA1 nuclear export utilized a CRM1-dependent mechanism and also required wild-type p53, whose function was abrogated by the E6 protein in MCF7 cells. In addition, the dependence on p53 was confirmed using a second cell type operating a tetracycline-inducible system. arpa dining tableWebInhibition of CRM1-mediated nuclear export by Leptomycin B resulted in nuclear accumulation of COMMD1. In addition, low oxygen concentrations induced the active export of COMMD1 from the nucleus in a CRM1-dependent manner. Disruption of the NESs in COMMD1 increased the repression of COMMD1 in transcriptional activity of NF-kappa B … bambu argentonaWebApr 13, 2024 · We specifically confirmed literature-derived interactions by immunoblotting anti-biotin immunoprecipitates from independent samples: KPNA2, RAN, and p53 for CSE1L (Fig. 5d, e) and Sec13, NUP160 ... arpadisk.ibrany.huWebMar 15, 2024 · Using proximity ligation assay (PLA) on NBAT1 sh and Csh SH-SY5Y cells, we observed that p53 and CRM1 interaction was higher in the NBAT1 sh cells when … bambu areca imagens