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Fip200的表达

WebNov 9, 2024 · ER Ca 2+ transient-induced, liquid-like FIP200 puncta attach to the ER by interacting with VAPA/B and ATL2/3 proteins. On the ER surface, puncta move, grow and merge during autophagosome formation. WebSep 1, 2024 · FIP200 also interacted with the TBK1 adaptor protein, AZI2, which was crucial for activation of TBK1 following FIP200 ablation. Accordingly, disrupting the noncanonical autophagy function of FIP200 in combination with ICI therapy led to superior, durable responses in immune-competent models of breast cancer. Collectively, these insights …

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WebApr 18, 2024 · FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52, as revealed by selective point mutations in their respective binding sites, but only in their combined presence does xenophagy proceed. Such recruitment of the upstream autophagy machinery by NDP52 reveals how detection of cargo-associated "eat me" … WebApr 28, 2008 · FIP200 is required for membrane targeting and proper function of ULK. (A) FIP200 +/− and FIP200 −/− MEFs stably expressing GFP-ULK1 or -ULK2 were cultured in starvation medium for 120 min. The cells were fixed and examined by fluorescence microscopy. Bar, 20 μm. (B) FIP200 +/+ and FIP200 −/− MEFs were cultured in complete … toby\u0027s horeca https://deanmechllc.com

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 ...

Web生物活性 [ 编辑] 所有的细胞都可以产生 干扰素-α （英语：Interferon alfa） 和 干扰素-β ， 而干扰素-γ只由 自然杀伤细胞 （NK细胞）和活化的 T细胞 产生。. I型干扰素对酸稳 … WebApr 23, 2024 · The VAPB P56S mutation, which is associated with amyotrophic lateral sclerosis, reduces the ULK1/FIP200 interaction and impairs autophagy at an early step, similar to the effect seen in VAPA/B-depleted cells. Our study reveals that VAPs directly interact with multiple ATG proteins, thereby contributing to ER/IM contact formation for ... WebFIP200是一个多功能蛋白， FIP200-ULK1-ATG13复合物对自噬体的形成是必需的。. 活性氧会在FIP200缺失的胚胎造血干细胞的线粒体中积累，提示FIP200可能参与调控活性氧的 … toby\u0027s hospital scary obby

生物物理所揭示内质网表面钙瞬变是多细胞生物自噬起 …

Category:FIP200, a key signaling node to coordinately regulate various …

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Fip200的表达

The ER Contact Proteins VAPA/B Interact with Multiple Autophagy ...

WebThe FIP200 CTR Directly Interacts with p62 in a LIR-Dependent Manner p62 contains a short region of weak homology with the Atg11-binding motif of yeast Atg19 (aa358–370 of p62) (Sawa-Makar-ska et al., 2014)(Figure S1A). At the same time, the CTR of FIP200 contains an Atg11 homology domain which shows WebFIP200 is composed of 1,594 residues, is essential for autophagy, and is considered the functional counterpart of the yeast Atg11 and Atg17 scaffold subunits (Hara et al., 2008; Fig. 1 A). FIP200, however, has no sequence homology to Atg11 and Atg17 apart from the C-terminal 100-residue CLAW domain of FIP200 and Atg11.

Fip200的表达

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WebOct 18, 2024 · fip200凝聚体通过与内质网膜蛋白vaps和atls结合，稳定定位于内质网上，并沿着内质网移动，与其他fip200凝聚体融合。 在达到一定大小后，FIP200凝聚体停止融 … WebMar 16, 2024 · 在一些选择性自噬过程中，自噬受体蛋白可通过结合ULK复合物中的FIP200亚基来招募和激活ULK复合物，并在自噬底物附近原位（in situ）介导自噬前体的形成。. 但是，目前自噬受体蛋白通过结合FIP200来招募ULK复合物的分子机理和相关的调控机制仍然未 …

WebOct 19, 2016 · 在自噬溶酶体组装前自噬信号是通过由 ulk1 或 ulk2、fip200 和 matg13 组成的 ulk 复合物的活化介导的。 ULK1 复合物在体内是连接上游营养或能量感受器 mTOR 和 AMPK 与下游自噬体形成的桥梁。 WebDec 13, 2024 · FIP200 is an essential autophagy gene implicated in the regulation of postnatal neural progenitor/stem cells (NSCs). However, the contribution of FIP200’s canonical-autophagy function and its ...

WebAug 10, 2024 · FIP200 and NDP52 samples for HDX were concentrated to a 20 μM stock solution, ULK1 complex was concentrated to a 10 μM stock solution, while POPS/POPI … WebMonoclonal Antibody for studying RB1CC1. Cited in 62 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, …

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WebSep 1, 2011 · Abstract. Autophagy is a lysosomal bulk degradation process for intracellular protein and organelles. FIP200 (200 kDa FAK-family interacting protein) is an essential component of mammalian autophagy that is implicated in breast cancer in recent studies. Here we show that inactivation of FIP200 resulted in deficient repair of DNA damage … toby\u0027s hinckley mnWebMar 21, 2024 · RB1CC1 (RB1 Inducible Coiled-Coil 1) is a Protein Coding gene. Diseases associated with RB1CC1 include Breast Cancer and Breast Adenocarcinoma . … toby\u0027s home repairWebJan 14, 2013 · Chano et al. (2002) found that 7 of 35 (20%) primary breast cancers examined contained mutations in RB1CC1, including 9 large interstitial deletions predicted to yield markedly truncated RB1CC1 proteins. In all 7 cases, the RB1CC1 gene in the germline was wildtype; all deletions represented somatic mutations. Wildtype RB1CC1 and RB1 … toby\u0027s homemade ice creamWebMar 10, 2024 · Interestingly, in contrast to the dramatic conformation arrangement of the FIP200 Claw dimer induced by the p-CCPG1 FIR-binding (Fig. 2b), the binding of p … penny\\u0027s battle themeWebNov 23, 2024 · K562 wild-type (WT) and FIP200 KO cells expressing tf-NBR1 or tf-LC3 were nucleofected with TagBFP or TagBFP-FIP200 and analyzed for red:green ratio and BFP … penny\u0027s battle themeWebRecent studies have identified FIP200 as a crucial signaling component to coordinately regulate different cellular events by its interaction with multiple signaling pathways. This review will focus on the cellular functions of FIP200 and its interacting proteins, as well as the emerging roles of FIP200 in embryogenesis and cancer development. penny\u0027s bathroom rugsWeb12421 Ensembl ENSG00000023287 ENSMUSG00000025907 UniProt Q8TDY2 Q9ESK9 RefSeq (mRNA) NM_001083617 NM_014781 NM_009826 RefSeq (protein) NP_001077086 NP_055596 NP_033956 Location (UCSC) Chr 8: 52.62 – 52.75 Mb Chr 1: 6.21 – 6.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse RB1-inducible coiled-coil … penny\\u0027s bathroom rugs